Key Employer

Bone Health

Osteoporosis is a bone disease that occurs when the body loses too much bone, makes too little bone, or both. As a result, bones become weak and may break from a fall or, in serious cases, from sneezing or minor bumps.6

Select risk factors for fracture include:7-10

Osteoporosis-related fractures can result in substantial clinical, psychological, and social burdens for patients.10-12


Examples of possible physical postfracture complications:

  • Limited activity
  • Pain
  • Postoperative hospitalization

After an osteoporosis-related fracture, some patients may experience:

  • Depression
  • Loss of independence
  • Decreased mobility



Osteoporosis carries a heavy economic burden for the healthcare system and potentially for employers.

Over 1,000 hospital admissions per 100,000 person-years from 2000- 2011 occurred due to osteoporosis, and the total cost associated with osteoporosis-related hospitalization exceeded that of myocardial infarction, stroke, or breast cancer.13

Total population cost for hospitalization for osteoporotic fractures
compared with other serious disease states, 2000–201113

Among these hospitalized patients could be employees in your plan.

In a 2010 study comparing privately insured patients that did or did not have an osteoporotic fracture*, fracture patients incurred:5

  • Additional direct medical costs of up to $13,801
  • Additional disability claims and days of missed work leading up to 2x higher annual work loss costs

Despite high direct and indirect costs, treatment rates and adherence to treatment are low, which maintain employer economic exposure to fracture.

  • Despite guideline recommendations, only 17% of women receive osteoporosis treatment after sustaining an osteoporosis-related fracture.14

  • Appropriate treatment can help reduce the risk of osteoporosis-related fractures.15

Subsequent fractures can cost up to three times more than initial fracture.16

Subsequent fractures cost more than initial fractures*

*Data Source: Thomson Reuters MarketScan Commercial Databases 2002-2008.


Corporate Level
Make bone health a priority in a full-spectrum approach to women's health.

Employee Level
Osteoporosis programs fit well into most existing wellness programs, overlapping with healthy eating, exercising, and smoking/drinking cessation programs.



Employer Alert: Osteoporosis in Women

Implications of osteoporosis in the workforce and suggested action steps to help employers manage costs and improve bone health outcomes


Bone Population Health Resources

Visit Amgen's Population Health website for useful resources and examples of improving employee bone health


Link to National Osteoporosis Foundation

Information and resources from the leading organization dedicated to bone health

References: 1. International Osteoporosis Foundation. Invest in your bones Osteoporosis in the Workplace. Accessed May 13, 2020.2. National Osteoporosis Foundation. Osteoporosis Fast Facts. Accessed May 13, 2020. 3. US Department of Health and Human Services. Bone Health and Osteoporosis: A Report of the Surgeon General. Rockville, MD; 2004.4. National Osteoporosis Foundation. Just for Men. just-for-men/. Accessed May 13, 2020. 5. Pike C, Birnbaum HG, Schiller M, Sharma H, Burge R, Edgell ET. Direct and indirect costs of non-vertebral fracture patients with osteoporosis in the US. Pharmacoeconomics. 2010;28:395-409. 6. National Osteoporosis Foundation. What is Osteoporosis and What Causes It? Accessed May 13, 2020. 7. Comacho PM, Petak SM, Binkley N, et al. American Association of Clinical Endocrinologists and American College of Endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis — 2016—executive summary. Endocr Pract. 2016;22(9):1111-1118. 8. Kanis JA. Diagnosis of osteoporosis and assessment of fracture risk. Lancet. 2002;359:1929-1936. 9. Kanis JA, Borgstrom F, De Laet C, et al. Assessment of fracture risk. Osteoporosis Int. 2005;16(6):581-589. 10. Colón-Emeric CS, Saag KG. Osteoporotic fractures in older adults. Best Pract Res Clin Rheumatol. 2006;20(4):695-706. 11. Dempster DW. Osteoporosis and the burden of osteoporosis-related fractures. Am J Manag Care. 2011;17:S164-S169. 12. National Osteoporosis Foundation. Clinician’s Guide to Prevention and Treatment of Osteoporosis. Washington, DC; National Osteoporosis Foundation; 2014. 13. Singer A, Exuzides A, Spangler L, et al. Burden of Illness for Osteoporotic Fractures Compared With Other Serious Diseases Among Postmenopausal Women in the United States. Mayo Clin Proc. 2015;90(1):53-62. 14. Boytsov NN, Crawford AG, Hazel-Fernandez LA, et al. Patient and provider characteristics associated with optimal post-fracture osteoporosis management. Am J Med Qual. 2017;32:644-654. 15. National Institute of Arthritis and Musculoskeletal and Skin Diseases. Once Is Enough: A Guide to Preventing Future Fractures. Accessed May 13, 2020. 16. Song X, Shi N, Badamgarav E, et al. Cost burden of second fracture in the US Health System. Bone. 2011;48:828-836.